publication . Article . Other literature type . 1997

Premature ovarian failure and ovarian autoimmunity.

A. Hoek; J. Schoemaker; H. A. Drexhage;
Open Access English
  • Published: 01 Feb 1997
  • Country: Netherlands
textabstractPremature ovarian failure (POF) is defined as a syndrome characterized by menopause before the age of 40 yr. The patients suffer from anovulation and hypoestrogenism. Approximately 1% of women will experience menopause before the age of 40 yr. POF is a heterogeneous disorder with a multicausal pathogenesis involving chromosomal, genetic, enzymatic, infectious, and iatrogenic causes. There remains, however, a group of POF patients without a known etiology, the so-called "idiopathic" form. An autoimmune etiology is hypothesized for the POF cases with a concomitant Addison's disease and/or oophoritis. It is concluded in this review that POF in associati...
Medical Subject Headings: endocrine system diseasesfemale genital diseases and pregnancy complications
free text keywords: Addison Disease/physiopathology, Antigen Presentation/physiology, Antigen-Presenting Cells/physiology, Autoimmune Diseases/genetics/physiopathology, Autoimmunity/*physiology, B-Lymphocytes/physiology, Disease Models, Animal, Female, Humans, Ovarian Failure, Premature/*immunology, Self Tolerance/*immunology, T-Lymphocytes/physiology, Endocrinology, Diabetes and Metabolism, Endocrinology
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