The remarkable similarity between the acid-base properties of ISFETs and proteins and the consequences for the design of ISFET biosensors

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Bergveld, P.; van Hal, R.E.G.; Eijkel, J.C.T.;

Studying the acid-base properties of protein molecules led us to reconsider the operational mechanism of ISFETs. Based on the site-dissociation model, applied to the amphoteric metal oxide gate materials used in ISFETs, the sensitivity of ISFETs is described in terms of... View more
  • References (18)
    18 references, page 1 of 2

    Bergveld, P. (1972). Development, operation and application of the ion-sensitive field-effect transistor as a tool for electrophysiology. IEEE Transaction Biomedical Engineering, vol. BME-19, 342-351.

    Bousse, L., de Rooy, N.F. & Bergveld, P. (1983). Operation of chemically sensitive field-effect sensors as a function of the insulator-electrolyte interface. I E E E Trans. on Electron Dev., vol ED30, 1263-1270.

    Bousse, L., Mostarshed, S., van der Schoot, B.H., de Rooij, N.F., Gimmel, P. & G6pel, W. (1991). Zeta potential measurements of Ta205 and SiO2 thin films. J. Colloid Int. Sci., 147, 22-32.

    Bousse, L.J., Mostarshed, S. & Hafeman, D. (1992). Combined measurement of surface potential and zeta potential at insulator/electrolyte interfaces. Sensors & Actuators, B-10, 67-71.

    Debye, P. & Hiickel, E. (1923). The theory of electrolytes I. Lowering of freezing point and related phenomena. Physik. Z., 24, 185-206.

    van Kerkhof, J.C., Eijkel, J.C.T. & Bergveld, P. (1994a). ISFET responses on a stepwise change in electrolyte concentration at constant pH, Sensors & Actuators, B-18, no. 1-3, 56-59.

    van Kerkhof, J.C., Bergveld, P. & Schasfoort, R.B.M. (1994b). A heparin sensor based on a modified TA2Os-ISFET and the ion-step measuring method. In: Proc. of the Dutch Conference on Sensor Technology 1994. P.V. Lambeck (ed.), Univ. of Twente, Enschede, The Netherlands, pp. 281-285, ISBN 90-73461-06-5.

    van Kerkhof, J.C., Bergveld, P. & Schasfoort, R.B.M. (1994c). The ISFET based heparine sensor with a monolayer of protamine as affinity ligand. Biosensors & Bioelectronics. (accepted).

    Kuriyama, T., Kimura, J. & Kawana. Y. (1985). Development of biosensors with immobilized enzyme. Chemical Economy & Engineering Rev., 17, 22-27.

    Linderstrc~m-Lang, K. (1924). The ionization of proteins. Compt. Rend. Trav. Lab. Carlsberg, S~r. Chim., 15, nr. 7.

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