publication . Article . Other literature type . 2016

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Okbay, Aysu; Baselmans, Bart M L; De Neve, Jan-Emmanuel; Turley, Patrick; Nivard, Michel G; Fontana, Mark Alan; Meddens, S Fleur W; Linnér, Richard Karlsson; Rietveld, Cornelius A; Derringer, Jaime; ...
Open Access English
  • Published: 01 Jun 2016 Journal: Nature Genetics, volume 48, issue 6, pages 624-633 (issn: 1061-4036, eissn: 1546-1718, Copyright policy)
Abstract
We conducted genome-wide association studies of three phenotypes: subjective wellbeing (SWB; N = 298,420), depressive symptoms (DS; N = 161,460), and neuroticism (N = 170,910). We identified three variants associated with SWB, two with DS, and eleven with neuroticism, including two inversion polymorphisms. The two DS loci replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (| | . ) strengthen the overall credibility of the findings, and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are st...
Subjects
free text keywords: MAJOR DEPRESSION, COMMON VARIANTS, HUMAN HEIGHT, RISK, HERITABILITY, METAANALYSIS, PERSONALITY, HAPPINESS, RESOURCE, DISEASE, ta3121, Article, well-being, genome-wide analysis, neuroticism, depression, behavioural genetics, genome-wide association studies, LifeLines Cohort Study, Humans, Bayes Theorem, Anxiety Disorders, Phenotype, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Developmental Biology, Biological Sciences, Medical and Health Sciences, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, [QFIN]Quantitative Finance [q-fin], ta3111, Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, 11 Medical And Health Sciences, 06 Biological Sciences, Anxiety Disorders/genetics; Bayes Theorem; Depression/genetics; Genome-Wide Association Study; Humans; Phenotype; Polymorphism, Single Nucleotide, Genetics, Clinical psychology, Biology, Subjective well-being, media_common.quotation_subject, media_common, Genetic association, Twin study, Life satisfaction, Anxiety, medicine.symptom, medicine
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NIH| Analysis of Genome-Wide Data in the Health and Retirement Study
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Rise of scientific excellence and collaboration for implementing personalised medicine in Estonia
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The molecular genetic architecture of educational attainment and its significance for cognitive health
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