publication . Doctoral thesis . 2015

Shedding light on canine pituitary dwarfism

Voorbij, A.M.W.Y.;
Open Access English
  • Published: 15 Sep 2015
  • Publisher: Utrecht University
  • Country: Netherlands
Abstract
Pituitary dwarfism, associated with growth hormone deficiency, is an autosomal, recessively inherited disorder in shepherd dogs. Due to the serious nature of pituitary dwarfism and lack of efficient treatment, it is preferable to prevent dwarfs from being born by applying a correct breeding policy. However, because pituitary dwarfism is a recessively inherited disorder and carriers do not differ phenotypically from non-carriers, genetic testing is required to prevent mating of 2 carriers. But before such a DNA-test could be developed, the mutated gene had to be identified first. The results of this thesis show that a contraction of a 7-bp DNA repeat in intron 5 ...
Subjects
Medical Subject Headings: endocrine system diseases
free text keywords: pituitary, dwarfism, DNA test, growth hormone, central hypothyroidism, LHX3, dogs
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Doctoral thesis . 2015
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