publication . Doctoral thesis . 2017

Unraveling lipid metabolism in lipid-dependent pathogenic Malassezia yeasts

Celis Ramirez, A.M.;
Open Access English
  • Published: 22 Nov 2017
  • Publisher: Utrecht University
  • Country: Netherlands
Abstract
Malassezia yeasts are lipid-dependent fungal species that are common members of the human and animal skin microbiota. The lipid-dependency is a crucial trait in the adaptation process to grow on the skin but also plays a role in their pathogenic life style. Malassezia species can cause several skin infections like dandruff or seborrheic dermatitis but also bloodstream infections. Understanding the lipid metabolism in Malassezia is essential to understand its life style as skin commensal and pathogen, however, many aspects about the lipid-synthesis pathways remain inconclusive. M. pachydermatis was considered to be the only lipid independent Malassezia species du...
Subjects
Medical Subject Headings: integumentary system
free text keywords: Malassezia, genome sequencing, metabolic reconstruction, lipid droplets, lipidomic, genetic transformation
Related Organizations
Download from
Utrecht University Repository
Doctoral thesis . 2017
Provider: NARCIS
49 references, page 1 of 4

1. T. Sugita, T. Boekhout, A. Velegraki, J. Guillot, S. Hadina, F.J. Cabañes, Epidemiology of Malassezia-Related Skin Diseases, in: T. Boekhout, P. Mayser, E. Guého-Kellermann, A. Velegraki (Eds.), Malassezia Ski. Sci. Clin. Pract., Springer Berlin Heidelberg, Berlin, Heidelberg, 2010: pp. 65-119. [OpenAIRE]

2. A. Tragiannidis, A. Groll, A. Velegraki, T. Boekhout, Malassezia Fungemia, antifungal susceptibility testing and epidemiology of nosocomial infections, in: T. Boekhout, P. Mayser, E. GuéhoKellermann, A. Velegraki (Eds.), Malassezia Ski. Sci. Clin. Pract., Springer Berlin Heidelberg, Berlin, Heidelberg, 2010: pp. 229-251. [OpenAIRE]

3. S. Triana, R.A. Ohm, H. De Cock, S. Restrepo, A. Celis, Draft genome sequence of the animal and human pathogen Malassezia pachydermatis strain CBS 1879, Genome Announc., 3 (2015) 5-6.

4. G. Wu, H. Zhao, C. Li, M.P. Rajapakse, W.C. Wong, J. Xu, C.W. Saunders, N.L. Reeder, R.A. Reilman, A. Scheynius, S. Sun, B.R. Billmyre, W. Li, A.F. Averette, P. Mieczkowski, J. Heitman, B. Theelen, M.S. Schröder, P.F. De Sessions, G. Butler, et al., Genus-wide comparative genomics of Malassezia delineates its phylogeny, physiology, and niche adaptation on human skin, PLoS Genet., 11 (2015) 1-26.

5. F.J. Cabanes, S.D.A. Coutinho, L. Puig, M.R. Bragulat, G. Castella, New lipid-dependent Malassezia species from parrots, Rev. Iberoam. Micol., 33 (2016) 92-99.

6. P. Honnavar, G.S. Prasad, A. Ghosh, S. Dogra, S. Handa, S.M. Rudramurthy, Malassezia arunalokei sp nov, a novel yeast species isolated from seborrhoeic dermatitis patients and healthy individuals from India, J. Clin. Microbiol., 54 (2016) 1826-1834. [OpenAIRE]

7. F.J. Cabañes, F.J. Cabanes, F.J. Cabañes, Malassezia yeasts: How many species infect humans and animals?, PLoS Pathog., 10 (2014) 1-4. [OpenAIRE]

8. G.R. Barber, A.E. Brown, T.E. Kiehn, F.F. Edwards, D. Armstrong, Catheter-related Malassezia furfur fungemia in immunocompromised patients, Am. J. Med., 95 (1993) 365-370.

9. E. Guého-Kellermann, T. Boekhout, D. Begerow, Biodiversity, phylogeny and ultrastructure, in: T. Boekhout, P. Mayser, E. Guého-Kellermann, A. Velegraki (Eds.), Malassezia Ski. Sci. Clin. Pract., Springer Berlin Heidelberg, Berlin, Heidelberg, 2010: pp. 17-63.

10. J. Xu, C.W. Saunders, P. Hu, R.A. Grant, T. Boekhout, E.E. Kuramae, J.W. Kronstad, Y.M. DeAngelis, N.L. Reeder, K.R. Johnstone, M. Leland, A.M. Fieno, W.M. Begley, Y. Sun, M.P. Lacey, T. Chaudhary, T. Keough, L. Chu, R. Sears, B.B. Yuan, et al., Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens, Proc. Natl. Acad. Sci. U. S. A., 104 (2007) 18730-18735.

11. A. Gioti, B. Nystedt, W. Li, J. Xu, A. Andersson, A.F. Averette, K. Münch, X. Wang, C. Kappauf, J.M. Kingsbury, B. Kraak, L.A. Walker, H.J. Johansson, T. Holm, J. Lehtiö, J.E. Stajich, P. Mieczkowski, R. Kahmann, J.C. Kennell, M.E. Cardenas, et al., Genomic insights into the atopic eczema-associated skin commensal yeast Malassezia sympodialis, MBio, 4 (2013) e00572- 12-e00572-12.

12. T. Boekhout, M. Kamp, E. Guého, Molecular typing of Malassezia species with PFGE and RAPD, Med. Mycol., 36 (1998) 365-372.

13. C.W. Saunders, A. Scheynius, J. Heitman, Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases, PLoS Pathog., 8 (2012). [OpenAIRE]

14. G.W. Gooday, Fungal sex hormones, Proc. Biochem. Soc., 127 (1972) 35-49.

15. P. Gladieux, J. Ropars, H. Badouin, A. Branca, G. Aguileta, D.M. de Vienne, R.C. Rodriguez de la Vega, S. Branco, T. Giraud, Fungal evolutionary genomics provides insight into the mechanisms of adaptive divergence in eukaryotes, Mol. Ecol., 23 (2014) 753-773. [OpenAIRE]

49 references, page 1 of 4
Abstract
Malassezia yeasts are lipid-dependent fungal species that are common members of the human and animal skin microbiota. The lipid-dependency is a crucial trait in the adaptation process to grow on the skin but also plays a role in their pathogenic life style. Malassezia species can cause several skin infections like dandruff or seborrheic dermatitis but also bloodstream infections. Understanding the lipid metabolism in Malassezia is essential to understand its life style as skin commensal and pathogen, however, many aspects about the lipid-synthesis pathways remain inconclusive. M. pachydermatis was considered to be the only lipid independent Malassezia species du...
Subjects
Medical Subject Headings: integumentary system
free text keywords: Malassezia, genome sequencing, metabolic reconstruction, lipid droplets, lipidomic, genetic transformation
Related Organizations
Download from
Utrecht University Repository
Doctoral thesis . 2017
Provider: NARCIS
49 references, page 1 of 4

1. T. Sugita, T. Boekhout, A. Velegraki, J. Guillot, S. Hadina, F.J. Cabañes, Epidemiology of Malassezia-Related Skin Diseases, in: T. Boekhout, P. Mayser, E. Guého-Kellermann, A. Velegraki (Eds.), Malassezia Ski. Sci. Clin. Pract., Springer Berlin Heidelberg, Berlin, Heidelberg, 2010: pp. 65-119. [OpenAIRE]

2. A. Tragiannidis, A. Groll, A. Velegraki, T. Boekhout, Malassezia Fungemia, antifungal susceptibility testing and epidemiology of nosocomial infections, in: T. Boekhout, P. Mayser, E. GuéhoKellermann, A. Velegraki (Eds.), Malassezia Ski. Sci. Clin. Pract., Springer Berlin Heidelberg, Berlin, Heidelberg, 2010: pp. 229-251. [OpenAIRE]

3. S. Triana, R.A. Ohm, H. De Cock, S. Restrepo, A. Celis, Draft genome sequence of the animal and human pathogen Malassezia pachydermatis strain CBS 1879, Genome Announc., 3 (2015) 5-6.

4. G. Wu, H. Zhao, C. Li, M.P. Rajapakse, W.C. Wong, J. Xu, C.W. Saunders, N.L. Reeder, R.A. Reilman, A. Scheynius, S. Sun, B.R. Billmyre, W. Li, A.F. Averette, P. Mieczkowski, J. Heitman, B. Theelen, M.S. Schröder, P.F. De Sessions, G. Butler, et al., Genus-wide comparative genomics of Malassezia delineates its phylogeny, physiology, and niche adaptation on human skin, PLoS Genet., 11 (2015) 1-26.

5. F.J. Cabanes, S.D.A. Coutinho, L. Puig, M.R. Bragulat, G. Castella, New lipid-dependent Malassezia species from parrots, Rev. Iberoam. Micol., 33 (2016) 92-99.

6. P. Honnavar, G.S. Prasad, A. Ghosh, S. Dogra, S. Handa, S.M. Rudramurthy, Malassezia arunalokei sp nov, a novel yeast species isolated from seborrhoeic dermatitis patients and healthy individuals from India, J. Clin. Microbiol., 54 (2016) 1826-1834. [OpenAIRE]

7. F.J. Cabañes, F.J. Cabanes, F.J. Cabañes, Malassezia yeasts: How many species infect humans and animals?, PLoS Pathog., 10 (2014) 1-4. [OpenAIRE]

8. G.R. Barber, A.E. Brown, T.E. Kiehn, F.F. Edwards, D. Armstrong, Catheter-related Malassezia furfur fungemia in immunocompromised patients, Am. J. Med., 95 (1993) 365-370.

9. E. Guého-Kellermann, T. Boekhout, D. Begerow, Biodiversity, phylogeny and ultrastructure, in: T. Boekhout, P. Mayser, E. Guého-Kellermann, A. Velegraki (Eds.), Malassezia Ski. Sci. Clin. Pract., Springer Berlin Heidelberg, Berlin, Heidelberg, 2010: pp. 17-63.

10. J. Xu, C.W. Saunders, P. Hu, R.A. Grant, T. Boekhout, E.E. Kuramae, J.W. Kronstad, Y.M. DeAngelis, N.L. Reeder, K.R. Johnstone, M. Leland, A.M. Fieno, W.M. Begley, Y. Sun, M.P. Lacey, T. Chaudhary, T. Keough, L. Chu, R. Sears, B.B. Yuan, et al., Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens, Proc. Natl. Acad. Sci. U. S. A., 104 (2007) 18730-18735.

11. A. Gioti, B. Nystedt, W. Li, J. Xu, A. Andersson, A.F. Averette, K. Münch, X. Wang, C. Kappauf, J.M. Kingsbury, B. Kraak, L.A. Walker, H.J. Johansson, T. Holm, J. Lehtiö, J.E. Stajich, P. Mieczkowski, R. Kahmann, J.C. Kennell, M.E. Cardenas, et al., Genomic insights into the atopic eczema-associated skin commensal yeast Malassezia sympodialis, MBio, 4 (2013) e00572- 12-e00572-12.

12. T. Boekhout, M. Kamp, E. Guého, Molecular typing of Malassezia species with PFGE and RAPD, Med. Mycol., 36 (1998) 365-372.

13. C.W. Saunders, A. Scheynius, J. Heitman, Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases, PLoS Pathog., 8 (2012). [OpenAIRE]

14. G.W. Gooday, Fungal sex hormones, Proc. Biochem. Soc., 127 (1972) 35-49.

15. P. Gladieux, J. Ropars, H. Badouin, A. Branca, G. Aguileta, D.M. de Vienne, R.C. Rodriguez de la Vega, S. Branco, T. Giraud, Fungal evolutionary genomics provides insight into the mechanisms of adaptive divergence in eukaryotes, Mol. Ecol., 23 (2014) 753-773. [OpenAIRE]

49 references, page 1 of 4
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