Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells

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Koning, GA; Gorter, A; Scherphof, GL; Kamps, JAAM;
(1999)
  • Subject: immunoliposomes | monoclonal antibody | colon cancer | tumour targeting | 5-fluorodeoxyuridine | drug delivery | BISPECIFIC MONOCLONAL-ANTIBODIES | STERICALLY STABILIZED LIPOSOMES | RAT-LIVER MACROPHAGES | COLORECTAL-CANCER | LIPID-COMPOSITION | COATED LIPOSOMES | METASTASIS MODEL | CARCINOMA MODEL | DRUG-DELIVERY | 3',5'-O-DIPALMITOYL-5-FLUORO-2'-DEOXYURIDINE | UMCG Approved

We have investigated the antiproliferative action towards CC531 colon adenocarcinoma cells of target cell-specific immunoliposomes containing the amphiphilic dipalmitoyl derivative of 5-fluorodeoxyuridine (FUdR-dP). FUdR-dP incorporated in immunoliposomes caused a 13-fo... View more
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