publication . Doctoral thesis . 2008

Evaluation of new drugs in daily clinical practice: anti-TNF alpha in rheumatoid arthritis patients.

Kievit, W.;
Open Access
  • Published: 01 Jan 2008
  • Publisher: [S.l. : s.n.]
  • Country: Netherlands
Abstract
The objective of this thesis was to explore the value and the validity of data collected in daily clinical practice for drug evaluation and cost-effectiveness studies, using data collected on TNFa blocking agents in rheumatoid arthritis. First, the need for and value of information from daily clinical practice was researched. Together, the results of Chapters 3, 4 and 5 illustrated that treatment of RA patients with anti-TNFa blocking agents in daily clinical practice was different from what was expected from the performed RCTs and the guidelines developed on the basis of the RCTs. Data from a daily clinical practice registry can be used to get insight in the ac...
Persistent Identifiers
Related Organizations
Download fromView all 2 versions
Radboud Repository
Doctoral thesis . 2008
Provider: NARCIS
21 references, page 1 of 2

Kwoh CK, Anderson LG, Greene JM, Johnson DA, O'Dell R, Robbins ML, Roberts WN, Simms RW, Yood RA. Guidelines for the management of rheumatoid arthritis - 2002 update. Arthritis and Rheumatism 2002; 46:328-346.

Gremillion RB, van Vollenhoven RF. Rheumatoid arthritis. Designing and implementing a treatment plan. Postgrad Med 1998; 103:103-108.

Welsing PM, Fransen J, van Riel PL. Is the disease course of rheumatoid arthritis becoming milder? Time trends since 1985 in an inception cohort of early rheumatoid arthritis. Arthritis Rheum 2005; 52:2616-2624. [OpenAIRE]

Guidelines for the management of rheumatoid arthritis: 2002 Update. Arthritis Rheum 2002; 46:328-346.

Keystone EC, Schiff MH, Kremer JM, Kafka S, Lovy M, DeVries T, Burge DJ. Once-weekly administration of 50 mg etanercept in patients with active rheumatoid arthritis: results of a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2004; 50:353- 363.

Weinblatt ME, Kremer JM, Bankhurst AD, Bulpitt KJ, Fleischmann RM, Fox RI, Jackson CG, Lange M, Burge DJ. A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 1999; 340:253-259.

Maini R, St Clair EW, Breedveld F, Furst D, Kalden J, Weisman M, Smolen J, Emery P, Harriman G, Feldmann M, Lipsky P. Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. Lancet 1999; 354:1932-1939.

TNF in rheumatoid arthritis, a comparison between randomized controlled trials and clinical practice. Ann Rheum Dis 2007; Furst DE, Breedveld FC, Kalden JR, Smolen JS, Burmester GR, Bijlsma JW, Dougados M, Emery P, Keystone EC, Klareskog L, Mease PJ. Updated consensus statement on biological agents, specifically tumour necrosis factor {alpha} (TNF{alpha}) blocking agents and interleukin-1 receptor antagonist (IL-1ra), for the treatment of rheumatic diseases, 2005. Ann Rheum Dis 2005; 64 Suppl 4:iv2-14.

Ledingham J, Deighton C. Update on the British Society for Rheumatology guidelines for prescribing TNFalpha blockers in adults with rheumatoid arthritis (update of previous guidelines of April 2001). Rheumatology (Oxford) 2005; 44:157-163. [OpenAIRE]

Modified Disease-Activity Scores That Include 28-Joint Counts - Development and Validation in A Prospective Longitudinal-Study of Patients with Rheumatoid-Arthritis. Arthritis and Rheumatism 1995; 38:44-48.

Pincus T, Yazici Y, Sokka T. Quantitative measures of rheumatic diseases for clinical research versus standard clinical care: differences, advantages and limitations. Best Practice & Research in Clinical Rheumatology 2007; 21:601-628.

Taylor WJ, Harrison AA, Highton J, Chapman P, Stamp L, Dockerty J, McQueen F, Jones PB, Ching D, Porter D, Rajapakse C, Rudge SR, Taylor G, Kumar S, Macedo T, Hoy MS. Disease Activity Score 28-ESR bears a similar relationship to treatment decisions across different rheumatologists, but misclassification is too frequent to replace physician judgement.

Rheumatology (Oxford) 2008; 47:514-518.

Yazici Y, Bergman M, Pincus T. Time to score quantitative rheumatoid arthritis measures: 28- Joint Count, Disease Activity Score, Health Assessment Questionnaire (HAQ), Multidimensional HAQ (MDHAQ), and Routine Assessment of Patient Index Data (RAPID) scores. J Rheumatol 2008; 35:603-609.

Pincus T, Sokka T. Quantitative measures for assessing rheumatoid arthritis in clinical trials and clinical care. Best Pract Res Clin Rheumatol 2003; 17:753-781.

21 references, page 1 of 2
Any information missing or wrong?Report an Issue