Reduced Synaptic Vesicle Recycling during Hypoxia in Cultured Cortical Neurons

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Fedorovich, Sergei; Hofmeijer, Jeannette; van Putten, Michel Johannes Antonius Maria; le Feber, Jakob;

Improvement of neuronal recovery in the ischemic penumbra, an area around the core of a brain infarct with some remaining perfusion, has a large potential for the development of therapy against acute ischemic stroke. However, mechanisms that lead to either recovery or s... View more
  • References (30)
    30 references, page 1 of 3

    Attwell, D., and Laughlin, S. B. (2001). An energy budget for signaling in the grey matter of the brain. J. Cereb. Blood Flow Metab. 21, 1133-1145. doi: 10.1097/00004647-200110000-00001

    Ayata, C., and Lauritzen, M. (2015). Spreading depression, spreading depolarizations, and the cerebral vasculature. Physiol. Rev. 95, 953-993. doi: 10.1152/physrev.00027.2014

    Bolay, H., Gürsoy-Özdemir, Y., Sara, Y., Onur, R., Can, A., and Dalkara, T. (2002). Persistent defect in transmitter release and synapsin phosphorylation in cerebral cortex after transient moderate ischemic injury. Stroke 33, 1369-1375. doi: 10.1161/

    Burrone, J., Li, Z., and Murthy, V. N. (2006). Studying vesicle cycling in presynaptic terminals using the genetically encoded probe synaptopHluorin. Nat. Prot. 1, 2970-2978. doi: 10.1038/nprot.2006.449

    Cochilla, A. J., Angleson, J. K., and Betz, W. J. (1999). Monitoring secretory membrane with FM1-43 fluorescence. Annu. Rev. Neurosci. 22, 1-10. doi: 10.1146/annurev.neuro.22.1.1

    Dittman, J., and Ryan, T. A. (2009). Molecular circuitry of endocytosis at nerve terminals. Annu. Rev. Cell Dev. Biol. 25, 133-160. doi: 10.1146/annurev.cellbio.042308.113302

    Gaffield, M. A., and Betz, W. J. (2006). Imaging synaptic vesicles exocytosis and endocytosis with FM dyes. Nat. Protoc. 1, 2916-2921. doi: 10.1038/nprot.2006.476

    Gao, T. M., Pulsinelli, W. A., and Xu, Z. C. (1999). Changes in membrane properties of CA1 pyramidal neurons after transient forebrain ischemia in vivo. Neuroscience 90, 771-780. doi: 10.1016/S0306-4522(98)00493-X

    George, P. M., and Steinberg, G. K. (2015). Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments. Neuron 87, 297-309. doi: 10.1016/j.neuron.2015.05.041

    Grote, J., Laue, O., Eiring, P., and Wehler, M. (1996). Evaluation of brain tissue O2 supply based on results of PO2 measurements with needle and surface microelectrodes. J. Auton. Nerv. Syst. 57, 168-172. doi: 10.1016/0165-1838(95)00096-8

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