publication . Article . 2005

Use of polyglutamic acids to reduce uptake of radiometal-labeled minigastrin in the kidneys.

Behe, M.; Kluge, G.; Becker, W.; Gotthardt, M.; Behr, T.M.;
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  • Published: 01 Jan 2005
  • Country: Netherlands
Abstract
Uptake of radiolabeled peptides in the kidneys may obscure abdominal tumors in radiopeptide scintigraphy. This problem is much more pronounced in peptide receptor radionuclide therapy (i.e., radiopeptide therapy), possibly leading to renal damage or even failure. Cationic peptide uptake in the kidneys can be reduced by the application of cationic amino acids, such as lysine or arginine. The aim of this study was to develop a suitable method to reduce anionic peptide uptake in the kidneys. (111)In-Diethylenetriaminepentaacetic acid dGlu(1)-minigastrin ((111)In-DTPA-dGlu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH(2)) was chosen as a model compound with a s...
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Article . 2005
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