The lac Operon: Fluctuations, Growth and Evolution

Doctoral thesis English OPEN
Kiviet, D.J.;

This thesis is concerned with two distinct fundamental research questions that are both investigated using the E. coli lac system. In the first chapters we investigate what the shape of biological fitness landscapes look like. Chapter 2 reviews recent progress in measur... View more
  • References (20)
    20 references, page 1 of 2

    [17] Campbell JH, Lengyel JA, Langridge J (1973) Evolution of a second gene for beta-galactosidase in Escherichia coli. Proc Natl Acad Sci USA 70:1841-1845. doi:10.1073/pnas.70.6.1841

    [18] Poelwijk FJ, Heijning P, de Vos MGJ, Kiviet DJ, Tans SJ (2010) Optimality and the evolution of transcriptionally regulated gene expression. Submitted to BMC Syst. Biol.

    [57] Kussell E, Leibler S (2005) Phenotypic diversity, population growth, and information in fluctuating environments. Science 309:2075-2078. doi:10.1126/science.1114383

    [58] Arnold FH, Wintrode PL, Miyazaki K, Gershenson A (2001) How enzymes adapt: lessons from directed evolution. Trends Biochem Sci 26:100-106. doi:10.1016/S0968-0004(00)01755-2

    [59] Elena SF, Lenski RE (2003) Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation. Nat Rev Genet 4:457-469. doi:10.1038/nrg1088

    [60] Couñago R, Chen S, Shamoo Y (2006) In vivo molecular evolution reveals biophysical origins of organismal fitness. Mol Cell 22:441-449. doi:10.1016/j.molcel.2006.04.012

    [62] Stephens SG (1951) Possible significance of duplication in evolution. Adv Genet 4:247-265. doi:10.1016/S0065-2660(08)60237-0

    [63] Ohno S (1970) Evolution by Gene Duplication. New York: Springer-Verlag.

    [64] Lynch M, Conery JS (2000) The evolutionary fate and consequences of duplicate genes. Science 290:1151-1155. doi:10.1126/science.290.5494.1151

    [65] Teichmann SA, Babu MM (2004) Gene regulatory network growth by duplication. Nat Genet 36:492-496. doi:10.1038/ng1340

  • Related Research Results (3)
  • Metrics
Share - Bookmark

  • Download from
    TU Delft Repository via NARCIS (Doctoral thesis, 2010)
  • Cite this publication