Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

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Holmes, Michael V; Dale, Caroline E; Zuccolo, Luisa; Silverwood, Richard J; Guo, Yiran; Ye, Zheng; Prieto-Merino, David; Dehghan, Abbas; Trompet, Stella; Wong, Andrew; Cavadino, Alana; Drogan, Dagmar; Padmanabhan, Sandosh; Li, Shanshan; Yesupriya, Ajay; Leusink, Maarten; Sundstrom, Johan; Hubacek, Jaroslav A; Pikhart, Hynek; Swerdlow, Daniel I; Panayiotou, Andrie G; Borinskaya, Svetlana A; Finan, Chris; Shah, Sonia; Kuchenbaecker, Karoline B; Shah, Tina; Engmann, Jorgen; Folkersen, Lasse; Eriksson, Per; Ricceri, Fulvio; ... view all 50 authors
(2014)
  • Subject: Models, Statistical | Biomarkers | Aged | Meta-Analysis | Alcohol Dehydrogenase | Mendelian Randomization Analysis | Middle Aged | Stroke | Alcohol Drinking | Research Support, Non-U.S. Gov't | Genotype | Research Support, U.S. Gov't, P.H.S. | Coronary Disease | Research Support, N.I.H., Extramural | Polymorphism, Single Nucleotide | Journal Article | Adult | Female | Genetic Markers | Humans | Male

OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PARTICIPANTS: 261 991 ... View more