publication . Doctoral thesis . 2010

Mitochondrial adaptations in insulin resistant muscle

Broek, van den, N.M.A.;
Open Access English
  • Published: 01 Jan 2010
  • Publisher: Technische Universiteit Eindhoven
  • Country: Netherlands
Abstract
Diabetes has reached epidemic proportions worldwide. Type 2 diabetes (T2D) accounts for about 90% of all diabetes cases and is characterized by insulin resistance (IR) in major metabolic tissues. The dramatic rise in T2D is associated with the increased occurrence of obesity and excessive ectopic lipid accumulation, in particular in skeletal muscle, due to excessive caloric intake and decreased physical activity. However, the exact processes leading to IR remain unresolved. One of the leading hypotheses in the research field of type 2 diabetes is that inherited or acquired skeletal muscle mitochondrial dysfunction, associated with a reduced mitochondrial capacit...
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Doctoral thesis . 2010
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