publication . Other literature type . Article . 2015

Enhanced Permeation of Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation characterization, In Vitro and Ex Vivo Studies

JAIN, C. P.; JOSHI, Garima; KATARIA, Udichi; PATEL, Komal;
Open Access English
  • Published: 29 Jul 2015 Journal: Scientia Pharmaceutica (issn: 2218-0532, Copyright policy)
  • Publisher: Multidisciplinary Digital Publishing Institute
Abstract
Buccal bioadhesive bilayer tablets of prochlorperazine maleate were designed and formulated by using buccoadhesive polymers such as hydroxypropylmethyl cellulose, Carbopol 934P, and sodium alginate. Physicochemical characteristics like the uniformity of weight, hardness, thickness, surface pH, drug content, swelling index, microenvironment pH, in vitro drug release, and in vivo buccoadhesion time of the prepared tablets were found to be dependent on the type and composition of the buccoadhesive materials used. The effect of bile salts on the permeation was studied through porcine buccal mucosa and it was found that out of three bile salts incorporated (sodium gl...
Subjects
free text keywords: Buccal tablet, Ex vivo, Antiemetic, Prochlorperazine, Bile salts, In vivo, Permeation, Prochlorperazine Maleate, Chemistry, Sodium, chemistry.chemical_element, Bioadhesive, Swelling, medicine.symptom, medicine, Buccal administration, Organic chemistry, Chromatography
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publication . Other literature type . Article . 2015

Enhanced Permeation of Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation characterization, In Vitro and Ex Vivo Studies

JAIN, C. P.; JOSHI, Garima; KATARIA, Udichi; PATEL, Komal;