Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons

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Singh, B.; Henneberger, C.; Betances, D.; Arevalo, M.A.; Rodriguez-Tebar, A.; Meier, J.C.; Grantyn, R.;
  • Publisher: Society for Neuroscience (U.S.A.)
  • Related identifiers: doi: 10.1523/JNEUROSCI.5474-05.2006
  • Subject: Retrograde messenger | Dendrite growth | 570 Life Sciences | Animals | Function and Dysfunction of the Nervous System | 610 Medical Sciences, Medicine | Synaptogenesis | Mice | E/I balance | bdnf knock-out | Neuron transfection
    mesheuropmc: nervous system

Cultured neurons from bdnf-/- mice display reduced densities of synaptic terminals, although in vivo these deficits are small or absent. Here we aimed at clarifying the local responses to postsynaptic brain-derived neurotrophic factor (BDNF). To this end, solitary enhan... View more
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