Chimeric polyomavirus-derived virus-like particles: the immunogenicity of an inserted peptide applied without adjuvant to mice depends on its insertion site and its flanking linker sequence

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Lawatscheck, R.; Aleksaite, E.; Schenk, J.A.; Micheel, B.; Jandrig, B.; Holland, G.; Sasnauskas, K.; Gedvilaite, A.; Ulrich, R.G.;
  • Publisher: Mary Ann Liebert (U.S.A.)
  • Related identifiers: doi: 10.1089/vim.2007.0023
  • Subject: Cancer Research
    mesheuropmc: biochemical phenomena, metabolism, and nutrition | viruses | virus diseases

We inserted the sequence of the carcinoembryonic antigen-derived T cell epitope CAP-1-6D (CEA) into different positions of the hamster polyomavirus major capsid protein VP1. Independently from additional flanking linkers, yeast-expressed VP1 proteins harboring the CEA i... View more
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