publication . Article . Other literature type . 2016

Association between reduced white matter integrity in the corpus callosum and serotonin transporter gene DNA methylation in medication-naive patients with major depressive disorder

Won, E; Choi, S; Kang, J; Kim, A; Han, K-M; Chang, H S; Tae, W S; Son, K R; Joe, S-H; Lee, M-S; ...
Open Access English
  • Published: 01 Aug 2016 Journal: Translational Psychiatry, volume 6, issue 8, page e866 (eissn: 2158-3188, Copyright policy)
  • Publisher: Nature Publishing Group
Abstract
Previous evidence suggests that the serotonin transporter gene (SLC6A4) is associated with the structure of brain regions that are critically involved in dysfunctional limbic-cortical network activity associated with major depressive disorder (MDD). Diffusion tensor imaging (DTI) and tract-based spatial statistics were used to investigate changes in white matter integrity in patients with MDD compared with healthy controls. A possible association between structural alterations in white matter tracts and DNA methylation of the SLC6A4 promoter region was also assessed. Thirty-five medication-naive patients with MDD (mean age: 40.34, male/female: 10/25) and age, ge...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Original Article, Biological Psychiatry, Cellular and Molecular Neuroscience, Psychiatry and Mental health, White matter, medicine.anatomical_structure, medicine, Serotonin transporter, biology.protein, biology, Developmental psychology, Fractional anisotropy, Corpus callosum, Major depressive disorder, medicine.disease, Psychology, Psychiatry, medicine.medical_specialty, DNA methylation, Genu of the corpus callosum, Regulation of gene expression
Related Organizations
67 references, page 1 of 5

Murphy ML, Frodl T. Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression. Biol Mood Anxiety Disord 2011; 1: 3.22738088 [OpenAIRE] [PubMed]

Konarski JZ, McIntyre RS, Kennedy SH, Rafi-Tari S, Soczynska JK, Ketter TA. Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder. Bipolar Disord 2008; 10: 1–37.

Choi S, Han KM, Won E, Yoon BJ, Lee MS, Ham BJ. Association of brain-derived neurotrophic factor DNA methylation and reduced white matter integrity in the anterior corona radiata in major depression. J Affect Disord 2014; 172C: 74–80.

Kieseppa T, Eerola M, Mantyla R, Neuvonen T, Poutanen VP, Luoma K et al. Major depressive disorder and white matter abnormalities: a diffusion tensor imaging study with tract-based spatial statistics. J Affect Disord 2010; 120: 240–244.19467559 [PubMed]

Kendler KS, Gatz M, Gardner CO, Pedersen NL. A Swedish national twin study of lifetime major depression. Am J Psychiatry 2006; 163: 109–114.16390897 [OpenAIRE] [PubMed]

Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM, Del-Favero J, Claes SJ, Oostra BA et al. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry 2008; 13: 772–785.17938638 [PubMed]

Dannlowski U, Kugel H, Redlich R, Halik A, Schneider I, Opel N et al. Serotonin transporter gene methylation is associated with hippocampal gray matter volume. Hum Brain Mapp 2014; 35: 5356–5367.24862560 [OpenAIRE] [PubMed]

Blakely RD, Ramamoorthy S, Schroeter S, Qian Y, Apparsundaram S, Galli A et al. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biol Psychiatry 1998; 44: 169–178.9693389 [PubMed]

Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 2003; 8: 646–653.12874600 [PubMed]

Smeraldi E, Zanardi R, Benedetti F, Di Bella D, Perez J, Catalano M. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol Psychiatry 1998; 3: 508–511.9857976 [PubMed]

McGowan PO, Kato T. Epigenetics in mood disorders. Environ Health Prev Med 2008; 13: 16–24.19568875 [OpenAIRE] [PubMed]

Karg K, Burmeister M, Shedden K, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry 2011; 68: 444–454.21199959 [OpenAIRE] [PubMed]

Devlin AM, Brain U, Austin J, Oberlander TF. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS One 2010; 5: e12201.20808944 [OpenAIRE] [PubMed]

Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A. The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 543–549.17987668 [OpenAIRE] [PubMed]

Kim JM, Stewart R, Kang HJ, Kim SW, Shin IS, Kim HR et al. A longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression. J Psychiatr Res 2013; 47: 1222–1227.23702251 [PubMed]

67 references, page 1 of 5
Abstract
Previous evidence suggests that the serotonin transporter gene (SLC6A4) is associated with the structure of brain regions that are critically involved in dysfunctional limbic-cortical network activity associated with major depressive disorder (MDD). Diffusion tensor imaging (DTI) and tract-based spatial statistics were used to investigate changes in white matter integrity in patients with MDD compared with healthy controls. A possible association between structural alterations in white matter tracts and DNA methylation of the SLC6A4 promoter region was also assessed. Thirty-five medication-naive patients with MDD (mean age: 40.34, male/female: 10/25) and age, ge...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Original Article, Biological Psychiatry, Cellular and Molecular Neuroscience, Psychiatry and Mental health, White matter, medicine.anatomical_structure, medicine, Serotonin transporter, biology.protein, biology, Developmental psychology, Fractional anisotropy, Corpus callosum, Major depressive disorder, medicine.disease, Psychology, Psychiatry, medicine.medical_specialty, DNA methylation, Genu of the corpus callosum, Regulation of gene expression
Related Organizations
67 references, page 1 of 5

Murphy ML, Frodl T. Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression. Biol Mood Anxiety Disord 2011; 1: 3.22738088 [OpenAIRE] [PubMed]

Konarski JZ, McIntyre RS, Kennedy SH, Rafi-Tari S, Soczynska JK, Ketter TA. Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder. Bipolar Disord 2008; 10: 1–37.

Choi S, Han KM, Won E, Yoon BJ, Lee MS, Ham BJ. Association of brain-derived neurotrophic factor DNA methylation and reduced white matter integrity in the anterior corona radiata in major depression. J Affect Disord 2014; 172C: 74–80.

Kieseppa T, Eerola M, Mantyla R, Neuvonen T, Poutanen VP, Luoma K et al. Major depressive disorder and white matter abnormalities: a diffusion tensor imaging study with tract-based spatial statistics. J Affect Disord 2010; 120: 240–244.19467559 [PubMed]

Kendler KS, Gatz M, Gardner CO, Pedersen NL. A Swedish national twin study of lifetime major depression. Am J Psychiatry 2006; 163: 109–114.16390897 [OpenAIRE] [PubMed]

Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM, Del-Favero J, Claes SJ, Oostra BA et al. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry 2008; 13: 772–785.17938638 [PubMed]

Dannlowski U, Kugel H, Redlich R, Halik A, Schneider I, Opel N et al. Serotonin transporter gene methylation is associated with hippocampal gray matter volume. Hum Brain Mapp 2014; 35: 5356–5367.24862560 [OpenAIRE] [PubMed]

Blakely RD, Ramamoorthy S, Schroeter S, Qian Y, Apparsundaram S, Galli A et al. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biol Psychiatry 1998; 44: 169–178.9693389 [PubMed]

Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 2003; 8: 646–653.12874600 [PubMed]

Smeraldi E, Zanardi R, Benedetti F, Di Bella D, Perez J, Catalano M. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol Psychiatry 1998; 3: 508–511.9857976 [PubMed]

McGowan PO, Kato T. Epigenetics in mood disorders. Environ Health Prev Med 2008; 13: 16–24.19568875 [OpenAIRE] [PubMed]

Karg K, Burmeister M, Shedden K, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry 2011; 68: 444–454.21199959 [OpenAIRE] [PubMed]

Devlin AM, Brain U, Austin J, Oberlander TF. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS One 2010; 5: e12201.20808944 [OpenAIRE] [PubMed]

Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A. The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 543–549.17987668 [OpenAIRE] [PubMed]

Kim JM, Stewart R, Kang HJ, Kim SW, Shin IS, Kim HR et al. A longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression. J Psychiatr Res 2013; 47: 1222–1227.23702251 [PubMed]

67 references, page 1 of 5
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publication . Article . Other literature type . 2016

Association between reduced white matter integrity in the corpus callosum and serotonin transporter gene DNA methylation in medication-naive patients with major depressive disorder

Won, E; Choi, S; Kang, J; Kim, A; Han, K-M; Chang, H S; Tae, W S; Son, K R; Joe, S-H; Lee, M-S; ...