publication . Article . 2016

A novel model of THO/TREX loading onto target RNAs in metazoan geneexpression

Hur, Junho K.; Chung, Yun Doo;
Open Access English
  • Published: 01 Jan 2016
Abstract
The THO/TREX complex consists of several conserved subunits and is required for mRNA export. In metazoans, THO/TREX binds a subset of mRNAs during RNA splicing, and facilitates their nuclear export. How THO/TREX selects RNA targets is, however, incompletely understood. In our recent study, we reported that THO is loaded onto Piwi-interacting RNA (piRNA) precursor transcripts independent of splicing, and facilitates convergent transcription in Drosophila ovary. The precursors are later processed into mature piRNAs, small noncoding RNAs that silence transposable elements (TEs). We observed that piRNAs originating from dual-strand clusters, where precursors are tra...
Subjects
Medical Subject Headings: endocrine systemurogenital system
free text keywords: Drosophila; Dual-strand piRNA cluster; piRNA; RDC(Rhino-Deadlock-Cutoff) complex; THO/TREX
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