Establishment of potent and specific synthetic substrate for dipeptidyl-peptidase 7

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Nemoto, Takayuki K.; Ono, Toshio; Ohara-Nemoto, Yuko;
  • Publisher: Elsevier Inc.
  • Journal: Analytical Biochemistry, volume 548, pages 78-81 (issn: 0003-2697)
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  • Subject: Dipeptidyl-peptidase 5 | Dipeptidyl-peptidase 7 | Periodontopathic bacteria | Porphyromonas gingivalis | Substrate specificity

Bacterial dipeptidyl-peptidase (DPP) 7 liberates a dipeptide with a preference for aliphatic and aromatic penultimate residues from the N-terminus. Although synthetic substrates are useful for activity measurements, those currently used are problematic, because they are... View more
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