publication . Doctoral thesis . 2007

Mechanism of induction of posterior vitreous detachment by intravireal plasmin infection, and development of a novel enzyme for pharmacologic vitreolysis

髙野, 晃臣; タカノ, アキオミ; Takano, Akiomi;
Open Access English
  • Published: 27 Mar 2007
  • Publisher: 熊本大学
Abstract
We demonstrated a dose-dependent increase in levels of active matrix metalloproteinase (MMP)-2 in the vitreous after plasmin injection. The time course of MMP-2 activity after plasmin administration showed that MMP-2 was significantly activated at 5 and 15 min after injection. Scanning electron microscopy demonstrated a smooth retinal surface in plasmin-teated eyes, suggesting the possibility that activation of endogenous MMP-2 by exogenous plasmin leads to induction of posterior vitreous detachment (PVD). In addition, we revealed the effects of intravitreal injection of nattokinase for induction of PVD. Nattokinase is a serine protease produced by Bacillus subt...
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Doctoral thesis . 2007
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