publication . Article . 2015

Multiple roles of hypoxia in ovarian function: roles of hypoxia-inducible factor-related and -unrelated signals during the luteal phase

Nishimura, Ryo; Okuda, Kiyoshi;
Open Access English
  • Published: 01 May 2015 Journal: Reproduction, Fertility and Development, volume 28, issue 10, pages 1,479-1,486 (issn: 1031-3613, Copyright policy)
  • Publisher: CSIRO Publishing
Abstract
There is increasing interest in the role of oxygen conditions in the microenvironment of organs because of the discovery of a hypoxia-specific transcription factor, namely hypoxia-inducible factor (HIF) 1. Ovarian function has several phases that change day by day, including ovulation, follicular growth and corpus luteum formation and regression. These phases are regulated by many factors, including pituitary hormones and local hormones, such as steroids, peptides and cytokines, as well as oxygen conditions. Hypoxia strongly induces angiogenesis because transcription of the potent angiogenic factor vascular endothelial growth factor (VEGF) is regulated by HIF1. ...
Subjects
Medical Subject Headings: endocrine system
free text keywords: angiogenesis, apoptosis, corpus luteum, follicular development, luteal formation, luteal regression, steroidogenesis
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Article . 2015
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