In Vivo Anti-estrogenic Effects of Menadione on Hepatic Estrogen-responsive Gene Expression in Male Medaka (Oryzias latipes)

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Yamaguchi, Akemi ; Kohra, Shinya ; Ishibashi, Hiroshi ; Arizono, Koji ; Tominaga, Nobuaki (2008)
  • Publisher: The Pharmaceutical Society of Japan
  • Journal: JOURNAL OF HEALTH SCIENCE, volume 54, issue 5, pages 596-601 (issn: 1344-9702)
  • Subject: menadione | anti-estrogenic | oryzias latipes, in vivo
    mesheuropmc: hormones, hormone substitutes, and hormone antagonists

Menadione, a synthetic vitamin K3, exhibits anti-estrogenic activity on in vitro assay. However, the in vivo anti-estrogenic effects of menadione have not been determined, while correlations between biological effects and structural changes are unclear. Thus, we investi... View more
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