Origin of the pKa shift of the catalytic lysine in acetoacetate decarboxylase.

Article English OPEN
Ishikita, Hiroshi;
(2010)
  • Publisher: Elsevier B.V.
  • Journal: FEBS letters, volume 584, issue 15, pages 3,464-3,468 (issn: 0014-5793)
  • Publisher copyright policies & self-archiving
  • Subject: Lysine | pKa | Acetoacetate decarboxylase | Hydrophobic | Solvation energy | Protein dielectric

The pKa value of Lys115, the catalytic residue in acetoacetate decarboxylate, was calculated using atomic coordinates of the X-ray crystal structure with consideration of the protonation states of all titratable sites in the protein. The calculated pKa value of Lys115 (... View more
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