publication . Research . 2005

Mouse Models of Graves' Disease

Nagayama, Yuji;
Open Access English
  • Published: 01 Jun 2005 Journal: Acta medica Nagasakiensia, volume 50, issue 2, pages 49-53 (issn: 0001-6055, Copyright policy)
Abstract
Graves' disease is characterized by overstimulation of the thyroid gland with agonistic autoantibodies against the thyrotropin (TSH) receptor, leading to hyperthyroidism and diffuse hyperplasia of the thyroid gland. Our and other laboratories have recently established several animal models of Graves' hyperthyroidism with novel immunization approaches, i.e., in vivo expression of the TSH receptor by injection of syngeneic living cells co-expressing the TSH receptor and major histocompatibility complex (MHC) class II or genetic immunization using plasmid or adenovirus vector coding the TSH receptor. This breakthrough has provided important insights into our unders...
Subjects
mesheuropmc: endocrine systemendocrine system diseases
free text keywords: Cytokine, Autoimmunity, Graves'disease, Adenovirus, Thyrotropinreceptor
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Research . 2005
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