publication . Research . 1998

RELATIONSHIP BETWEEN URIC ACID METABOLISM AND INSULIN RESISTANCE

辻本, 伸宏; 金内, 雅夫; 尾崎, 博基; 藤田, 泰三; 中嶋, 民夫; 土肥, 和紘;
Open Access Japanese
  • Published: 31 Oct 1998 Journal: Journal of Nara Medical Association, volume 49, issue 5, pages 349-352 (issn: 1345-0069, Copyright policy)
  • Publisher: 奈良医学会
Abstract
To investigate the relationship between uric acid (UA) metabolism and insulin resistance, serum creatinine concentration (Scr), serum UA concentration (SuA) and the urinary excretion of creatinine and UA were determined in 25 non-diabetic patients. Creatinine clearance (Ccr) and UA clearance/creatinine clearance ratio (CuA/Ccr) were also calculated. Insulin resistance was evaluated by the euglycemic glucose clamp tech- nique and expressed as the mean value of the glucose infusion rate (M-value). Scr and Ccr did not show any correlation with the M-value. SuA showed a significant negative correla- tion with the M-value, and CuA/Ccr showed a positive correlation wi...
Subjects
Medical Subject Headings: integumentary system
free text keywords: glucose clamp technique, insulin resistance, uric acid metabolism
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Research . 1998
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