SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus

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Kawaguchi, Yuka ; Nariki, Hiroaki ; Kawamoto, Naoko ; Kanehiro, Yuichi ; Miyazaki, Satoshi ; Suzuki, Mari ; Magari, Masaki ; Tokumitsu, Hiroshi ; Kanayama, Naoki (2017)
  • Publisher: Elsevier
  • Journal: Biochemical and Biophysical Research Communications, volume 485, issue 2, pages 261-266 (issn: 0006-291X)
  • Subject: AID | DT40 | Gene conversion | Ig | SRSF1 | Somatic hypermutation

Activation-induced cytidine deaminase (AID) is essential for diversification of the Ig variable region (IgV). AID is excluded from the nucleus, where it normally functions. However, the molecular mechanisms responsible for regulating AID localization remain to be elucid... View more
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