Pleiotropic Actions of Helicobacter pylori Vacuolating Cytotoxin, VacA

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Isomoto, Hajime; Moss, Joel; Hirayama, Toshiya;
  • Publisher: Tohoku University Medical Press
  • Journal: The Tohoku Journal of Experimental Medicine,volume 220,issue 1,pages3-14 (issn: 0040-8727)
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  • Subject: Helicobacter pylori | Vacuolating toxin | VacA
    mesheuropmc: bacteria | bacterial infections and mycoses | digestive system diseases

Helicobacter pylori produces a vacuolating cytotoxin, VacA, and most virulent H. pylori strains secrete VacA. VacA binds to two types of receptor-like protein tyrosine phosphatase (RPTP), RPTPα and RPTPβ, on the surface of host cells. VacA bound to RPTPβ, relocates and ... View more
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