publication . Article . 2010

Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA.

Hajime Isomoto; Joel Moss; Toshiya Hirayama;
  • Published: 01 Jan 2010
  • Publisher: Tohoku University Medical Press
Abstract
Helicobacter pylori produces a vacuolating cytotoxin, VacA, and most virulent H. pylori strains secrete VacA. VacA binds to two types of receptor-like protein tyrosine phosphatase (RPTP), RPTPα and RPTPβ, on the surface of host cells. VacA bound to RPTPβ, relocates and concentrates in lipid rafts in the plasma membrane. VacA causes vacuolization, membrane anion-selective channel and pore formation, and disruption of endosomal and lysosomal activity in host cells. Secreted VacA is processed into p33 and p55 fragments. The p55 domain not only plays a role in binding to target cells but also in the formation of oligomeric structures and anionic membrane channels. O...
Subjects
Medical Subject Headings: digestive system diseasesbacterial infections and mycosesbacteria
free text keywords: Helicobacter pylori, VacA, Vacuolating toxin, General Biochemistry, Genetics and Molecular Biology, General Medicine, Signal transduction, Microbiology, Cytotoxic T cell, CagA, Lipid raft, biology.organism_classification, biology, Protein tyrosine phosphatase, PI3K/AKT/mTOR pathway, Secretion
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publication . Article . 2010

Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA.

Hajime Isomoto; Joel Moss; Toshiya Hirayama;