publication . Article . 2002

自然発症高血圧ラットにおける釣藤散の抗高血圧作用 : 釣藤鈎及び石膏の役割について

趙, 琦; 渡辺, 裕司; 村上, 孝寿; 東田, 道久; 松本, 欣三;
Open Access English
  • Published: 01 Aug 2002 Journal: 和漢医薬学雑誌 = Journal of traditional medicines, volume 19, issue 4, pages 153-157 (issn: 1340-6302, Copyright policy)
  • Publisher: 和漢医薬学会
Abstract
To clarify a role of Chotoko (Uncaria sp.) and gypsum in the anti-hypertensive effect of a Kampo prescription Choto-san (Diao-Teng-San), we investigated effects of Choto-san except Chotoko or gypsum, Chotoko alone and gyp-sum alone on the blood pressure and the heart rate in spontaneously hypertensive rats (SHR). Choto-san (0.5, 1.0 and 2.0 g/kg, p.o.) produced a dose-dependent hypotensive effect, but did not affect the heart rate in SHR. It affected neither blood pressure nor heart rate in normotensive Wistar-Kyoto (WKY) rats. When Chotoko was removed from the Choto-san prescription, the hypotensive effect of Choto-san disappeared. When gypsum was taken away fr...
Subjects
free text keywords: Choto-san, gypsum, Uncaria sp., spontaneously hypertensive rats, hypertension
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Article . 2002
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