publication . Research . 2002

Neuronal Migration and Neuronal Migration Disorder in Cerebral Cortex

SUN, Xue-Zhi; TAKAHASHI, Sentaro; GUI, Chun; ZHANG, Rui; KOGA, Kazuo; NOUYE, Minoru; MURATA, Yoshiharu;
Open Access English
  • Published: 01 Dec 2002 Journal: Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University, volume 46, issue 1/2, pages 7-15 (issn: 0287-0517, Copyright policy)
  • Publisher: Research Institute of Environmental Medicine, Nagoya University
Abstract
Neuronal cell migration is one of the most significant features during cortical development. After final mitosis, neurons migrate from the ventricular zone into the cortical plate, and then establish neuronal lamina and settle onto the outermost layer, forming an "inside-out" gradient of maturation. Neuronal migration is guided by radial glial fibers and also needs proper receptors, ligands, and other unknown extracellular factors, requests local signaling (e.g. some emitted by the Cajal-Retzius cells of the marginal zone) to stop neuronal migration. This process is highly sensitive to various physical, chemical and biological agents as well as to genetic mutati...
Subjects
mesheuropmc: nervous system
free text keywords: cerebrum, ventricular zone, heterotopic mass, radial glial cel, cell migration
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Research . 2002
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