Effect of Restricted Feeding Times on the Longevity and Serum Biochemistry of Male Sprague-Dawley Rats
Kawasaki journal of medical welfare,
restricted feeding times | longevity | serum biochemistry | Sprague-Dawley rat
The effect of limiting the daily feeding times on longevity and serum biochemistry was studied in adult male Sprague--Dawley rats. Groups 1H, 6H and 12H received a commercial stock diet for one, six and twelve hours daily, respectively. The control group was fed the same diet ad libitum. The final body weight of group 1H was significantly lower, and longevity was significantly greater than in the other three groups. Group 1H consumed only 67% of the intake of the ad libitum group. After 36 weeks, the serum albumin of group 1H remained at initial values, and age-related increases in serum lipids were lower than in the other groups. These results suggest that a lower food intake, i.e 67% of ad libitum food intake as in Group 1H, may be effective in preventing obesity and aging in male Sprague--Dawley rats.