publication . Article . 2002

Genotoxicity of extracts of Japanese traditional herbal medicines (Kampo)

Makoto, Katami; Haruo, Kuboniwa; Shunichi, Maemura; Toshihiko, Yanagisawa; New Drug Discovery Laboratory, R & D Division, TSUMURA & Co.; New Drug Discovery Laboratory, R & D Division, TSUMURA & Co.; New Drug Discovery Laboratory, R & D Division, TSUMURA & Co.; New Drug Discovery Laboratory, R & D Division, TSUMURA & Co.;
Open Access English
  • Published: 31 May 2002 Journal: 環境変異原研究 = Environmental mutagen research communication, volume 24, issue 1, pages 1-15 (issn: 0910-0865, Copyright policy)
Abstract
The possible genotoxicity potential of 128 Japanese traditional herbal medicines (Kampo) was investigated using a bacterial reverse mutation test (the Ames test), an in vivo micronucleus test (MN test) in mouse bone marrow cells and an unscheduled DNA synthesis test (UDS test) in rat hepatocytes. Of 128 Kampo extracts examined, 98 did not induce mutations in bacteria while 30 induced mutations weakly in Salmonella typhimurium TA1537. Extracts of Scutellariae Radix, a common herbal drug, and its major components, wogonin, baicalin, and baicalein showed positive responses in the Ames test. Among 30 Ames-positive Kampo extracts, 27 contained these major components ...
Subjects
free text keywords: Japanese traditional herbal medicines (Kampo), genotoxicity, Ames test, micronucleus test, unscheduled DNA synthesis test
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Article . 2002
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