Downregulation of miR-15a due to LMP1 promotes cell proliferation and predicts poor prognosis in nasal NK/T-cell lymphoma.

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駒林, 優樹; 岸部, 幹; 長門, 利純; 上田, 征吾; 高原, 幹; 原渕, 保明;
  • Journal: American journal of hematology, volume 89, issue 1, pages 25-33 (issn: 0361-8609)
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  • Subject: Nasal natural killer/T cell lymphoma | microRNA-15a | Epstein-Barr virus | v-myb myeloblastosis viral oncogene homolog | cyclin D1 | Epstein-Barr virus latent membrane protein 1

Nasal NK/T-cell lymphoma (NNKTL) is an Epstein-Barr virus (EBV)-associated malignancy and has distinct clinical and histological features. However, its genetic features are hitherto unclear. MicroRNAs (miRNAs) play a crucial role in the pathogenesis of several malignanc... View more
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