publication . Article . 2002

Normal and abnormal neuronal migration in the developing cerebral cortex

Sun, Xue-Zhi; Takahashi, Sentaro; Cui, Chun; Zhang, Rui; Sakata-Haga, Hiromi; Sawada, Kazuhiko; Fukui, Yoshihiro;
Open Access English
  • Published: 01 Jan 2002 Journal: The journal of medical investigation : JMI, volume 49, issue 3-4, pages 97-110 (issn: 1343-1420, Copyright policy)
Abstract
Neuronal migration is the critical cellular process which initiates histogenesis of cerebral cortex. Migration involves a series of complex cell interactions and transformation. After completing their final mitosis, neurons migrate from the ventricular zone into the cortical plate, and then establish neuronal lamina and settle onto the outermost layer, forming an “inside-out” gradient of maturation. This process is guided by radial glial fibers, requires proper receptors, ligands, other unknown extracellular factors, and local signaling to stop neuronal migration. This process is also highly sensitive to various physical, chemical and biological agents as well a...
Subjects
Medical Subject Headings: nervous system
free text keywords: cerebrum, ectopia, migration disorder, radial glia
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Article . 2002
Provider: JAIRO
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