publication . Article . 2015

genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation

Yumi Kohara; Shinichiro Kawaguchi; Rika Kuwahara; Yutaro Uchida; Yushi Oku; Kimihiro Yamashita;
Open Access
  • Published: 01 Mar 2015 Journal: Physiology & Behavior, volume 140, pages 15-22 (issn: 0031-9384, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Cognitive dysfunction due to higher blood glucose level has been reported previously. Genistein (GEN) is a phytoestrogen that we hypothesized might lead to improved memory, despite elevated blood glucose levels at the time of memory consolidation. To investigate this hypothesis, we compared the effects of orally administered GEN on the central nervous system in normal versus glucose-loaded adult male rats. A battery of behavioral assessments was carried out. In the MAZE test, which measured spatial learning and memory, the time of normal rats was shortened by GEN treatment compared to the vehicle group, but only in the early stages of testing. In the gl...
Subjects
free text keywords: Experimental and Cognitive Psychology, Behavioral Neuroscience, Memory consolidation, Endocrinology, medicine.medical_specialty, medicine, Cognition, Emotionality, Diabetes mellitus, medicine.disease, Habituation, Genistein, chemistry.chemical_compound, chemistry, Central nervous system, medicine.anatomical_structure, Internal medicine, Oral administration, Psychology, Glucose load, Phytoestrogen, Rat, Spatial learning
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publication . Article . 2015

genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation

Yumi Kohara; Shinichiro Kawaguchi; Rika Kuwahara; Yutaro Uchida; Yushi Oku; Kimihiro Yamashita;