publication . Research . 2017

Anti-interleukin-13, a Monoclonal Antibody, in Uncontrolled Asthma: Systematic Review and Meta-analysis

ANDO Koichi:筆頭著者:責任著者; TANAKA Akihiko; HOMMA Tetsuya; OHNISHI Tsukasa; INOUE Shin; SAGARA Hironori;
Open Access English
  • Published: 01 Dec 2017 Journal: Showa Univ J Med Sci, volume 29, issue 4, pages 353-364 (issn: 0915-6380, Copyright policy)
  • Publisher: Showa University Society
Abstract
The overall efficacy and safety of anti-interleukin (IL)-13 therapies remain to be fully characterized. We conducted a meta-analysis of randomized controlled trials (RCTs) on the efficacy and safety of anti-IL-13 therapies compared with placebo in patients with uncontrolled asthma. This meta-analysis complied with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary efficacy outcome was pulmonary function, and the primary safety outcome was the incidence rate of all adverse events (AAEs). Secondary outcomes included asthma exacerbation, asthma control, and asthma-related quality of life (QoL). Pooled estimates a...
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Research . 2017
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