publication . Article . 2014

Aspartame-induced apoptosis in PC12 cells

Horio, Yukari; Sun, Yongkun; Liu, Chuang; Saito, Takeshi; Kurasaki, Masaaki;
Open Access English
  • Published: 01 Jan 2014 Journal: Environmental Toxicology and Pharmacology, volume 37, issue 1, pages 158-165 (issn: 1382-6689, Copyright policy)
  • Publisher: Elsevier, B.V.
Abstract
Aspartame is an artificial sweetner added to many low-calorie foods. The safety of aspartame remains controversial even though there are many studies on its risks. In this study, to understand the physiological effects of trace amounts of artificial sweetners on cells, the effects of aspartame on apoptosis were investigated using a PC12 cell system. In addition, the mechanism of apoptosis induced by aspartame in PC12 cells and effects on apoptotic factors such as cytochrome c, apoptosis-inducing factor, and caspase family proteins were studied by Western blotting and RT-PCR. Aspartame-induced apoptosis in PC12 cells in a dose-dependent manner. In addition, a...
Subjects
free text keywords: Aspartame, Apoptosis, Caspases, AIF, PC12, Cytochrome c
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Article . 2014
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