publication . Article . 2010

Quantitative trait locus analysis of ovarian cysts derived from rete ovarii in MRL/MpJ mice

Lee, Shin-hyo; Ichii, Osamu; Otsuka, Saori; Hashimoto, Yoshiharu; Kon, Yasuhiro;
Open Access English
  • Published: 01 Apr 2010 Journal: Mammalian Genome, volume 21, issue 3-4, pages 162-171 (issn: 0938-8990, Copyright policy)
  • Publisher: Springer New York
Abstract
MRL/MpJ (MRL) is a model mouse for autoimmune diseases that shows dermatitis, vasculitis, arthritis, and glomerulonephritis. In addition to these immune-associated disorders, we found that aged MRL mice develop ovarian cysts originating from the rete ovarii, which is lined by ciliated or nonciliated epithelium and considered remnants of mesonephric tubules. Ovarian cysts, which are reported to have several sources, are associated with female infertility, but information regarding the genetic etiology of ovarian cysts originating from the rete ovarii is rare. In this study, to elucidate the genetic background of development of ovarian cysts, we performed quantita...
Subjects
Medical Subject Headings: endocrine systemfemale genital diseases and pregnancy complications
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Article . 2010
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