publication . Article . 2003

Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia: development by concerted actions of BMP signaling

Suzuki, Kentaro; Daniel, Bachiller; Chen, YiPing P.; Kamikawa, Mami; Ogi, Hidenao; Haraguchi, Ryuma; Ogino, Yukiko; Minami, Yasuhiro; Mishina, Yuji; Ahn, Kyung; ...
Open Access
  • Published: 01 Dec 2003 Journal: Development, volume 130, pages 6,209-6,220 (issn: 0950-1991, eissn: 1477-9129, Copyright policy)
  • Publisher: The Company of Biologists
Abstract
Extra-corporal fertilization depends on the formation of copulatory organs: the external genitalia. Coordinated growth and differentiation of the genital tubercle (GT), an embryonic anlage of external genitalia, generates a proximodistally elongated structure suitable for copulation, erection, uresis and ejaculation. Despite recent progress in molecular embryology, few attempts have been made to elucidate the molecular developmental processes of external genitalia formation. Bone morphogenetic protein genes (Bmp genes) and their antagonists were spatiotemporally expressed during GT development. Exogenously applied BMP increased apoptosis of GT and inhibited its ...
Subjects
Medical Subject Headings: embryonic structures
free text keywords: Developmental Biology, Molecular Biology, Genital tubercle, BMPR1A, Anatomy, FGF8, Biology, Bone morphogenetic protein, Days post coitum, Cell growth, Downregulation and upregulation, Noggin, Genetics, External genitalia, BMP, WNT5A, Apoptosis, Cell proliferation, Distal urethral epithelium
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publication . Article . 2003

Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia: development by concerted actions of BMP signaling

Suzuki, Kentaro; Daniel, Bachiller; Chen, YiPing P.; Kamikawa, Mami; Ogi, Hidenao; Haraguchi, Ryuma; Ogino, Yukiko; Minami, Yasuhiro; Mishina, Yuji; Ahn, Kyung; ...