publication . Research . 2007

Post-Transcriptional Regulation by the Csr Global Regulatory System in Escherichia coli

Suzuki, Kazushi; 鈴木, 一史;
Open Access English
  • Published: 01 Mar 2007 Journal: 新潟大学農学部研究報告, volume 59, issue 2, pages 56-63 (issn: 0385-8634, Copyright policy)
  • Publisher: 新潟大学農学部
Abstract
In many species of bacteria, the Csr (carbon storage regulator) global regulatory system coordinates the expression of various genes. In Escherichia coli, the central component of this system, CsrA, is a RNA-binding protein. The CsrA is a homodimer and binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated by two small non-coding RNAs, CsrB and CsrC. These RNAs contain multiple CsrA-binding sequences and act by sequestering CsrA. In this system, CsrA indirectly activates transcription of csrB and csrC through a two-component signal transduction system, BarA/UvrY. Another component of this system, CsrD, con...
Subjects
free text keywords: Csr A, Csr system, EAL domain, GGDEF domain, small RNA, EAL ドメイン, Csr システム, GGDEF ドメイン
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Research . 2007
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