publication . Article . 1996

Analysis of Pathogenesis of Autoimmune Insulitis in NOD Mice: Adoptive Transfer Experiments of Insulitis in ILI and NOD Nude Mice

Nakamura, Moritaka; Nishimura, Masahiko; Koide, Yukio; Takato, O.Yoshida;
Open Access
  • Published: 01 Jan 1996 Journal: Experimental Animals, volume 45, pages 233-238 (issn: 1341-1357, Copyright policy)
  • Publisher: Japanese Association for Laboratory Animal Science
Abstract
In an effort to study the pathophysiological events in the development of insulitis in NOD mice, we have developed ILI- and NOD-nu/nu mice. ILI mice are a nondiabetic inbred strain but are derived from the same Jcl:ICR mouse as NOD mice and share the same H-2 allotype with NOD mice. Splenocytes and CD4+ cells from diabetic NOD mice appeared to transfer insulitis to ILI-nu/nu mice, suggesting that ILI mice already express autoantigen(s) responsible for insulitis. But reciprocal thymic grafts from NOD mice into ILI-nu/nu mice and those from ILI mice into NOD-nu/nu mice failed to allow the development of insulitis, implying that ILI mice possess neither precursor T...
Subjects
Medical Subject Headings: virus diseasesrespiratory tract diseases
free text keywords: Splenocyte, Pathogenesis, Endocrinology, medicine.medical_specialty, medicine, Biology, Internal medicine, Inbred strain, Nod, Adoptive cell transfer, Immunology, Allotype, Insulitis, medicine.disease, NOD mice, ILI mice, Insulitis susceptibility gene, nude mice
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publication . Article . 1996

Analysis of Pathogenesis of Autoimmune Insulitis in NOD Mice: Adoptive Transfer Experiments of Insulitis in ILI and NOD Nude Mice

Nakamura, Moritaka; Nishimura, Masahiko; Koide, Yukio; Takato, O.Yoshida;