publication . Article . 2003

Effects of Choto-san and Chotoko on thiopental-induced sleeping time

JEENAPONGSA, Rattima; Tohda, Michihisa; Watanabe, Hiroshi;
Open Access English
  • Published: 01 Aug 2003 Journal: 和漢医薬学雑誌 = Journal of traditional medicines, volume 20, issue 4, pages 165-167 (issn: 1340-6302, Copyright policy)
  • Publisher: 和漢医薬学会
Choto-san has been used for treatment of centrally regulated disorders such as dementia, hypertension, headache and vertigo. Our laboratory showed that Choto-san improved learning memory in ischemic mice. It is noticeable that Choto-san treated animals and animals that underwent conducting occlusion of common carotid arteries (2VO) operation slept longer than the normal animals. Therefore, this study aimed to clarify the effects of Choto-san and its related component; Chotoko and Choto-san without Chotoko on thiopental-induced sleeping time. The results show that Choto-san (0.3, 1 and 3 g/kg, p.o.) dose dependently prolonged the sleeping time induced by thiopent...
free text keywords: Choto-san, Uncaria sp., Uncaria rhynchophylla, Uncaria sinensis, thiopental-induced sleep
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Article . 2003
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