Prevention of Post Transfusion Hepatitis Employing Sensitive Assay for Hepatitis B Surface Antigen Screening(Topics in Transfusion Medicine 1990 : Autologous Transfusion and Post-Transfusion Hepatitis)

Research Japanese OPEN
小島, 秀男 ; 大竹, 幸子 ; 富樫, 和枝 ; 石口, 重子 ; 山田, 恵子 ; 品田, 章二 ; Kojima, Hideo ; Ohtake, Sachiko ; Togashi, Kazue ; Ishiguchi, Shigeko ; Yamada, Keiko ; Shinada, Shoji (1990)
  • Publisher: 新潟医学会
  • Journal: 新潟医学会雑誌, volume 104, issue 12, pages 992-998 (issn: 0029-0440)
  • Subject: C型肝炎ウイルス | B型肝炎ウイルス | post transfusion hepatitis | 輸血後肝炎 | HCV | HBV
    mesheuropmc: virus diseases | digestive system diseases

Post transfusion Hepatitis (PTH) is one of serious side effects and some times lead to fulminant hepatic failure in case transfused blood contain very low level (under the sensitivity of usual screening method) of hepatitis B virus (HBV). Redcross blood center and blood transfusion devision of our hospital have been employed reverse passive hemmaglutination method (RPHA) for HBsAg screening. Authors employed EIA for sensitive HBsAg test system and compared with RPHA method. Of 2,255 sera from blood bonors, 21 sera showed HBsAg by EIA. Of those 21 HBsAg sera, 4 were negative for HBsAg when tested by RPHA. So about 20% of HBsAg positive sera containing very low level HBV and RPHA could not detect them. For the prevention of post transfusion type B hepatitis, authors changed the HBsAg screening method to EIA. Relationship with so called non-A non-B hepatitis and anti-HCV was investigted. Anti-HCV was detected frequently in patients clinically diagnosed as non-A non-B hepatitis, and correlation of anti-HCV positivity and blood transfusion indicates the importance of the anti-HCV screening in blood transfusion.
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