publication . Article . 2015

Self-organizing Map Analysis for Understanding Comprehensive Relationships between Formulation Variables, State of Water, and the Physical Stability of Pharmaceutical Emulsions

Onuki, Yoshinori; Hasegawa, Naoki; Horita, Akihiro; Ueno, Naomi; Kida, Chihiro; Hayashi, Yoshihiro; Obata, Yasuko; Toshokan, Toshokan;
Open Access English
  • Published: 01 Nov 2015 Journal: Chemical and Pharmaceutical Bulletin, volume 63, issue 11, pages 901-906 (issn: 1347-5223, Copyright policy)
  • Publisher: 日本薬学会
Abstract
The physical stability of pharmaceutical emulsions is an important quality attribute to be considered. To obtain a better understanding of this issue, this study investigated the contribution of the state of water to the physical stability of pharmaceutical emulsions. The key technology to evaluate the state of water was magnetic resonance imaging (MRI). For sample preparation, model emulsions with different formulation variables (surfactant content, water content, and hydrophilic–lipophilic balance) were prepared. The T1 relaxation time, diffusion coefficient, and viscosity were measured as physical properties. The physical stability of the samples was evaluate...
Subjects
free text keywords: pharmaceutical emulsion, magnetic resonance imaging, physical stability, T1 relaxation time, diffusion coefficient
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Article . 2015
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