publication . Article . 2004

DNA array analysis of gene expression changes by Choto-san in the ischemic rat brain

Tohda, Michihisa; Matsumoto, Kinzo; Hayashi, Hisae; Murakami, Yukihisa; Watanabe, Hiroshi;
Open Access English
  • Published: 01 Aug 2004 Journal: 和漢医薬学雑誌 = Journal of traditional medicines, volume 21, issue 4, pages 182-186 (issn: 1880-1447, Copyright policy)
  • Publisher: 和漢医薬学会
Abstract
The effects of Choto-san on gene expression in the dementia model rat brain were studied using a DNA microarray system. Choto-san inhibited the expression of 181 genes that has been enhanced by permanent occlusion of the bilateral common carotid arteries (2VO). Choto-san also reversed the expression inhibition of 32 genes induced by 2VO. These results may suggest that Choto-san, which has been therapeutically used as an antidementive drug, shows therapeutic effects through gene expression changes痴呆モデル動物である両側総頸動脈永久結紮ラット脳中での釣藤散による遺伝子発現変化をDNAマイクロアレイ法により検討した。被検4,277種の遺伝子中181種類の発現が脳虚血4日後の脳中で上昇し,釣藤散1g/kg 1日1回3日間経口投与により回復することが明らかとなった。また,32種類の発現が,脳虚血により減少し,釣藤散で回復することもわか...
Subjects
free text keywords: Choto-san, dementia, gene expression, DNA microarray, ischemia, rat brain
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Article . 2004
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