Gestational Age-Dependent Increase of Survival Motor Neuron Protein in Umbilical Cord-Derived Mesenchymal Stem Cells

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Iwatani, Sota; Harahap, Nur Imma Fatimah; Nurputra, Dian Kesumapramudya; Tairaku, Shinya; Shono, Akemi; Kurokawa, Daisuke; Yamana, Keiji; Thwin, Khin Kyae Mon; Yoshida, Makiko; Mizobuchi, Masami; Koda, Tsubasa; Fujioka, Kazumichi; Taniguchi-Ikeda, Mariko; Yamada, Hideto; Morioka, Ichiro; Iijima, Kazumoto; Nishio, Hisahide; Nishimura, Noriyuki;
(2017)
  • Publisher: Frontiers Media
  • Journal: Frontiers in Pediatrics,volume 5,page194 (issn: 2296-2360, eissn: 2296-2360)
  • Related identifiers: doi: 10.3389/fped.2017.00194, doi: 10.3389/fped.2017.00194/full, pmc: PMC5591793
  • Subject: RJ1-570 | Pediatrics | Original Research | spinal muscular atrophy | umbilical cord-derived mesenchymal stem cell | gestational age | perinatal development | survival motor neuron-targeted therapy
    mesheuropmc: nervous system diseases | nervous system | animal diseases

Background Spinal muscular atrophy (SMA) is the most common genetic neurological disease leading to infant death. It is caused by loss of survival motor neuron (SMN) 1 gene and subsequent reduction of SMN protein in motor neurons. Because SMN is ubiquitously expresse... View more
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