publication . Part of book or chapter of book . 2012

Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic Approaches

Hanane Akhdar; Claire Legendre; Caroline Aninat; Fabrice More;
Open Access English
  • Published: 22 Feb 2012
  • Publisher: InTech
Abstract
Over the last decades, several studies have demonstrated that cancer cells have a unique metabolism compared to normal cells (Herling et al., 2011). Metabolic changes occurring in cancer cells are considered to be fundamental for the transformation of normal cells into cancer cells and are also responsible for the resistance to different types of chemotherapeutic drugs (Cree, 2011). Therefore, resistance to chemotherapy represents a major problem in the treatment of several tumor types. Among the different metabolic and signalling pathways that are altered in cancer cells, variations in the expression and activity of several drugmetabolizing enzymes play a criti...
Subjects
free text keywords: Cancer cell, Drug resistance, Chemotherapy, medicine.medical_treatment, medicine, Enzyme, chemistry.chemical_classification, chemistry, Multiple drug resistance, Drug, media_common.quotation_subject, media_common, Drug metabolism, Pharmacology, Cross-resistance, business.industry, business
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publication . Part of book or chapter of book . 2012

Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic Approaches

Hanane Akhdar; Claire Legendre; Caroline Aninat; Fabrice More;