publication . Part of book or chapter of book . 2012

The Functionality of p53 in Thyroid Cancer

Ray, Debolina; Balmer, Matthew T.; Gal, Susannah;
Open Access
  • Published: 21 Mar 2012
  • Publisher: InTech
Abstract
Abnormalities in several important cellular pathways and processes are often a major contributing factor to the progression of cancer. The cell cycle is regulated by checkpoint proteins, including the cyclins and cyclin dependent protein kinases (cdk), which play an important role in the prevention of aberrant cell division. Normal cells have the ability to stop cell division and initiate DNA repair or apoptosis (programmed cell death) when genomic abnormalities cannot be repaired. Apoptotic signaling is necessary for the elimination of unwanted cells arising from exposure to stress or toxins or as a function of normal tissue development and senescence. Proteins...
Subjects
free text keywords: Programmed cell death, DNA repair, Cell division, Apoptosis, Cyclin-dependent kinase, biology.protein, biology, Cyclin, Cell cycle, Cell biology, Cancer cell
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Part of book or chapter of book . 2012
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Part of book or chapter of book . 2012
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