publication . Article . Other literature type . 2018

Treatment of Diabetic Mice with a Combination of Ketogenic Diet and Aerobic Exercise via Modulations of PPARs Gene Programs

Qiang Zhang; Lingyan Xu; Jie Xia; Dongmei Wang; Min Qian; Shuzhe Ding;
Open Access English
  • Published: 01 Mar 2018 Journal: PPAR Research, volume 2,018 (issn: 1687-4757, eissn: 1687-4765, Copyright policy)
  • Publisher: Hindawi
Abstract
<jats:p>Type 2 diabetes is a prevalent chronic disease arising as a serious public health problem worldwide. Diet intervention is considered to be a critical strategy in glycemic control of diabetic patients. Recently, the low-carbohydrate ketogenic diet is shown to be effective in glycemic control and weight loss. However, hepatic lipid accumulation could be observed in mice treated with ketogenic diet. On the other hand, exercise is a well-known approach for treating nonalcoholic fatty liver disease. We thus hypothesize that the combination of ketogenic diet and exercise could improve insulin sensitivity, while minimizing adverse effect of hepatic steatosis. I...
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free text keywords: Research Article, Article Subject, Pharmacology (medical), Drug Discovery, lcsh:Biology (General), lcsh:QH301-705.5, Aerobic exercise, Ketogenic diet, medicine.medical_treatment, medicine, Nonalcoholic fatty liver disease, medicine.disease, Weight loss, medicine.symptom, Internal medicine, medicine.medical_specialty, Glycemic, Steatosis, Type 2 diabetes, Diabetes mellitus, business.industry, business, Endocrinology
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