Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder

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Fuchs, Claudia; Gennaccaro, Laura; Trazzi, Stefania; Bastianini, Stefano; Bettini, Simone; Martire, Viviana Lo; Ren, Elisa; Medici, Giorgio; Zoccoli, Giovanna; Rimondini, Roberto; Ciani, Elisabetta*;
(2018)
  • Publisher: Hindawi
  • Journal: Neural Plasticity,volume 2,018 (issn: 2090-5904, eissn: 1687-5443)
  • Related identifiers: pmc: PMC5994305, doi: 10.1155/2018/9726950
  • Subject: Spasms, Infantile | Neurology (clinical) | Research Article | Neurosciences. Biological psychiatry. Neuropsychiatry | Signal Transduction | RC321-571 | Behavior, Animal | Brain | Heterozygote | Mice, Knockout | Mice, Inbred C57BL | Disease Models, Animal | Rett Syndrome | Epileptic Syndromes | Protein-Serine-Threonine Kinases | Animals | Female | Article Subject | Neurology

CDKL5 disorder is a severe neurodevelopmental disorder caused by mutations in the X-linked CDKL5 (cyclin-dependent kinase-like five) gene. CDKL5 disorder primarily affects girls and is characterized by early-onset epileptic seizures, gross motor impairment, intellectual... View more
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