publication . Article . 2000

Gas‒phase reactions of NO+ with Glu and γ‒Glu–Met

Wincel, H.; Fokkens, R. H.; Nibbering, N. M. M.;
Open Access English
  • Published: 01 Jan 2000 Journal: Spectroscopy (issn: 0712-4813, Copyright policy)
  • Publisher: Hindawi Publishing Corporation
Abstract
The reactivity of the nitrosonium ion, NO+, with the amino acid Glu and the dipeptide γ‒Glu–Met in the gas phase has been investigated using the combination of chemical ionisation mass spectrometry and MS/MS. It is shown that NO+ reacts efficiently with both Glu and Glu–Met leading to the formation of the nitroso‒group containing ions at m/z 159 and 288.The formation of m/z 159, (GluNO‒18)+, is rationalized by a mechanism involving an electrophilic attack of NO+ upon the carbonyl oxygen atom of one of the carboxylic groups of Glu and the N‒terminal carboxylic group of Glu–Met leading to the neutral losses of H2O and Met, respectively. The unimolecular decomposit...
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