publication . Article . 2009

Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice.

Chen, Baoan; Cheng, Jian; Wu, Yanan; Gao, Feng; Xu, Wenlin; Shen, Huilin; Ding, Jiahua; Gao, Chong; Sun, Qian; Sun, Xinchen; ...
Open Access English
  • Published: 18 Mar 2009 Journal: International Journal of Nanomedicine (issn: 1176-9114, eissn: 1178-2013, Copyright policy)
  • Publisher: Dove Medical Press
Abstract
Multidrug resistance (MDR) is a well-defined phenomenon of cross-resistance of mammalian cells to a number of anticancer agents following exposure to one such drug. It is a major obstacle to successful chemotherapy in leukemia.1 More than 90% of patients with malignant tumor die of MDR. A diverse range of agents involved in MDR include alkaloid compounds and bacterial and fungal antibiotics such as anthracyclines and etoposide. An accepted mechanism of MDR is a reduced cellular accumulation and an altered subcellular distribution of cytotoxic drugs. In many instances, this is mediated by increased expression at the cell surface of the MDR1 gene product, P-glycop...
Subjects
free text keywords: International Journal of Nanomedicine, Medicine (General), R5-920, Original Research, 5-bromotetrandrine, magnetic nanoparticle of Fe3O4, multidrug-resistance, xenograft model, Biophysics, Organic Chemistry, Bioengineering, Drug Discovery, Biomaterials, General Medicine, Multiple drug resistance, In vitro, Cytotoxicity, In vivo, Daunorubicin, medicine.drug, medicine, Efflux, Pharmacology, K562 cells, Etoposide, Biology
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publication . Article . 2009

Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice.

Chen, Baoan; Cheng, Jian; Wu, Yanan; Gao, Feng; Xu, Wenlin; Shen, Huilin; Ding, Jiahua; Gao, Chong; Sun, Qian; Sun, Xinchen; ...